Fig. 2

Fundus photographs and OCT images of typical cases with effective and resistant nAMD before and one year after treatment. A–D show a 68-year-old man with effective nAMD; E–H show a 58-year-old man with resistant nAMD. A–D The 68-year-old man with PCV in the left eye underwent six IVI treatments in one year. VA improved from 0.16 logMAR pre-treatment to 0 logMAR one year after treatment. Pre-treatment SAF level was 2.1 AU. A Fundus photograph pre-treatment showing a small subretinal hemorrhage and orange-red lesions in the fovea, surrounded by SRD. B Fundus photograph one year after treatment showing no SRD. C OCT image pre-treatment showing high, small PED surrounded by SRD. D OCT image one year after treatment showing reduced PED with no SRD. E–H The 58-year-old man with PCV in the left eye underwent seven IVI treatments in one year. VA changed from 0.22 logMAR to 0.16 logMAR one year after treatment, but no meaningful change was observed. Pre-treatment SAF level was 2.9 AU. E Fundus photograph pre-treatment showing a moderate subretinal hemorrhage and orange-red lesions in the fovea, surrounded by SRD. F Fundus photograph one year after treatment showing no hemorrhage; a white atrophic region was present in the fovea. G OCT image pre-treatment showing a low, small PED surrounded by SRD. H OCT image one year after treatment showing no remarkable change in foveal morphology; the PED reduced but the SRD remained