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Table 3 Correlation analysis between baseline biomarker levels and changes in BCVA and treatment interval

From: Deep learning assisted analysis of biomarker changes in refractory neovascular AMD after switch to faricimab

 

ΔBCVA (mo0 - mo9)

ΔInterval (mo0 - mo9)

r

p-value

r

p-value

CRT (mo0)

0.25

0.0394

0.25

0.0399

IRF (mo0)

-0.06

0.6965

0.06

0.3250

SRF (mo0)

-0.01

0.9554

0.28

0.0316

fvPED (mo0)

0.18

0.0422

0.17

0.0369

SHRM (mo0)

-0.04

0.7831

-0.09

0.2642

Choroid (mo0)

-0.04

0.7582

-0.01

0.2236

  1. This table displays the Spearman correlation coefficients (r) and corresponding p-values for the relationship between baseline biomarker levels and changes in best-corrected visual acuity (ΔBCVA, logMAR) and treatment interval (ΔInterval, days) from mo0 to mo9. Central retinal thickness (CRT) and fibrovascular pigment epithelium detachment (fvPED) at mo0 show a positive correlation with BCVA improvement, while CRT and subretinal fluid (SRF) levels at baseline are significantly associated with an extended treatment interval. Significant p-values are indicated in bold, suggesting that higher initial CRT, SRF, and fvPED values may predict more favorable treatment responses in refractory nAMD patients switched to Faricimab