Fig. 1

1A Multimodal Assessment with SS-OCT and SS-OCT-Angiography of a patient participating in this study, who received treatment with a loading dose of aflibercept (40 mg/ml) 0,05 ml/2 mg. 1A Pretreatment: Color Retinography: presence of diabetic retinopathy (microaneurysms and cotton wool exudates). 2A Posttreatment Color Retinography. All images that begin with number 1 correspond to pretreatment, and all images that begin with number 2 correspond to posttreatment. Image 1B B-Scan SSOCT: delimitation of macular thickness, where we observe the presence of diabetic macular edema. 2B: Posttreatment: B-scan without macular edema. 1C ETDRS map with central macular thickness of 402 µm, and 2C posttreatment with central macular thickness of 241 µm. 1D B-Scan with choroidal thickness delimitation, and 2D choroidal thickness posttreatment. 1E Central choroidal thickness of 224 µm pretreatment. And 2E: showing reduction to 214 µm. 1F Avascular Area of the Superficial Plexus pretreatment: 299.597 µm², and 2F: with posttreatment reduction to 197.358 µm². 1G Avascular Area of the Deep Plexus pretreatment: 655.767 µm², and 2G posttreatment with reduction to 257.871 µm². 1H B-Scan: presence of macular edema (intraretinal cysts), the red colors represent areas of greater flow according to the analysis performed by the Imaginet 6 software algorithm. 2H Posttreatment B-Scan, absence of macular edema. 1I Vessel Density Map = 21.10 corresponding to the central. 2I shows decreased Central Vessel Density = 13.43 and 1J Red Free pretreatment: presence of microaneurysms and cotton-wool exudates. 2J Red Free posttreatment